We show here the firsts images of human microvasculature, observed in the nose, ear, mastoid and neck that are supposed to exhibit healthy vasculature.
Lower, we propose some applications in cancerology by showing the firsts vasculature images of human and mouse melanoma obtained with the MV1 Microvasculoscope.
Finally, we show a movie exhibiting the potentiel of this system to follow in real time the healing process of the skin.
With the MV1 micro-vasculoscope, we detected a permeation nodule on a patient that would have been interpreted as a nevus according to the usual rule ABCDE on the classical image (a). By observing the microvascular activity with the MV1 system, an intense signal appears and reflects the strong growth of this tumor (b). (c) is a superposition of (a) and (b).
On the human, the diagnosis is based on the usual rule ABCDE of classical observation:
A: for Asymmetry
B: For irregular edges, the edges are poorly defined.
C: for inhomogeneous color, varying from one zone to another of the lesion.
D: for Diameter which is often greater than 6 mm.
E: for Evolution: the aspect of the lesion in its size especially, its shape, or its color has changed.
(Toulouse Oncopole /ONERA)
A suspect naevus exhibit a strong activity (a). A benign nevus (b) completely disappears in the microvascular activity signal (c) observed with the MV1 system.
A very early observation of a B16 melanoma implanted in a mouse 6 days before.
(a) gray image (b) corresponding microvascular activity image observed with the MV1 system and (c) superposition.
Microvascularization reaction of the skin following a small scratch on a hand. Immediately after the scratch, a centimeter square zone is activated and we observe the blood that converges toward the scratch in a few minutes.