Brand new images of human microvascularization
We show here the firsts images of human microvasculature, observed in the nose, ear, mastoid and neck that are supposed to exhibit healthy vasculature. Lower, we propose some applications in cancerology by showing the firsts vasculature images of human and mouse melanoma obtained with the MV1 Microvasculoscope. Finally, we show a movie exhibiting the potentiel of this system to follow in real time the healing process of the skin.
Skin Cancer of Human
With the MV1 Micro-Vasculoscope, we detected a permeation nodule on a patient that could have been interpreted as a nevus according to the usual ABCDE rule on the conventional image (a). By observing the microvascular activity with the MV1 system, an intense signal appears and reflects the strong growth of this tumor (b).
On the human, the diagnosis is based on the usual ABCDE rule of classical observation:
A: for Asymmetry
B: for irregular Borders, the edges being poorly defined
C: for inhomogeneous Color, varying from one zone to another in the lesion
D: for Diameter which is often greater than 6 mm
E: for Evolution: the aspect of the lesion changes with time (size, shape, and/or color)
(Images : Toulouse Oncopole /ONERA)
Study of the melanoma B16 on mouse
A very early observation of a B16 melanoma implanted in a mouse 6 days before.
(a) gray image (b) corresponding microvascular activity image observed with the MV1 system and (c) superposition.
normal naevi disappear in the microvascularization activity image
A benign nevus doens't exhibit any abnormal microvascular activity. This is due to the fact that it undergoes the same micro vascular activity than the surrounding skin.
On the contrary, the 3th and 4th images show an abnormal nevus that exhibits a strong vascular activity, including the presence of centimetric ramifications.
Microvascularization reaction of the skin following a small scratch on a hand. Immediately after the scratch, a centimeter square zone is activated and we observe the blood that converges toward the scratch in a few minutes.